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The acronym, NAT, is the more broad-spectrum arylamine N-acetyltransferase that also acetylates serotonin, which allows for the production of melatonin in species that are deficient in AANAT and incorrectly defined as melatonin knock out ( Figure 1 Quay was the first to document that pineal melatonin synthesis was cyclic and that its production was clearly higher at night than during the day ( Figure 1 )

It strengthens biological plausibility considerably

Reis GS, Augusto VS, Silveira AP, et al

Importantly, SCFAs can cross the BBB via monocarboxylate transporters located on endothelial cells and influence BBB integrity by upregulating the expression of tight junction proteins [186] and thereby potentially exert direct effects on microglia